Microfluidic Probes: EPILEPSY Research in HUMAN awarded by FIPSE

Posted By Borja Barredo / News / epilepsy, idival, Lab on a Chip, microfluidics, neuron, Neuroscience, parkinson / No hay comentarios

Microfluidic Probes for EPILEPSY Research

Microfluidic microprobes to record neuronal activity and local application of drugs, to be applied to the electrophysiological monitoring or pre-surgical intra-operative of adult patients with refractory epilepsy, awarded with the FIPSE Project in Phase 1.

fprobes - microfluidic microprobes for epilepsy research

fprobes – microfluidic microprobes for epilepsy research

 

This project, coordinated by the Department of Neurophysiology at the Hospital Marqués de Valdecilla-Valdecilla Health Research Institute (IDIVAL) (Dr. José Luis Fernández Torre), integrates researchers from the CSIC Cajal Institute in Madrid (Dr. Liset Menendez de la Prida ) and the  microLIQUID in Basque Country (Dr. Ane Altuna), a multidisciplinary team with a long research career in their respective fields of expertise.

Dr. José Luis Fernández Torre is the principal investigator of this project, is Head of Clinical Neurophysiology, University Hospital Marqués de Valdecilla, Vice president of the National Committee for Clinical Neurophysiology, Associate Professor in the Department of Physiology and Pharmacology, Faculty of Medicine Santander (UNICAN) and creator and in charge  of the Research group  for clinical research associate of Neurophysiology in Epilepsy and Neurointensives in the Valdecilla Research Institute (IDIVAL). He has published over 80 articles in prestigious journals such as Clinical Neurophysiology, Epilepsy, Neurology and Journal Neurology, Neurosurgery and Psyschiatry.

Liset Menendez de la Prida is doctor in Neuroscience (1998) in the program of the prestigious Institute of Neurosciences of Alicante, is an international expert in the study of the neural mechanisms of high frequency oscillations (or HFOs) in epilepsy. She has participated in numerous international projects of the European Commission and prestigious institutions such as the Human Frontier Science Program, and published in the top journals in the field as Neuron and Nature Neuroscience. It has 5 accredited six-year research periods for her scientific activity, she has directed four doctoral theses and has 2 ongoing, and regularly participates as a speaker at the prestigious Gordon Conference on Epilepsy and guest in prestigious foreign institutions.

Ane Altuna is doctor by the University of the Basque Country (2012), currently head of R & D in Microliquid, she developed her career in science and technology in IKERLAN where she designed and finalized the production of integrated electrical probes for brain recording. Expert in SU-8, biocompatible polymer that makes up the structural material of our integrated probes, has published her work in the most prestigious journals in the field, such as Lab-on-chip or Biosensors and Bioelectronics.

 

microfluidic microprobes for Epilepsy Research

microfluidic microprobes – Epilepsy

 

The aim of the project is to assess the feasibility of integrated microscopic probes (<150 microns diameter) aimed to record neuronal activity and to deliver drugs locally for preoperative or intraoperative electrophysiological monitoring of adult patients with refractory epilepsy evaluated for surgery or and neurocritical patients (in coma) with spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, malignant stroke and severe head trauma during continuous multimodal monitoring. With this project they intend to evaluate: a) the clinical opportunity for intracranial integrated recordings and local drug delivery solutions; b) the technical adjustments required to bring current experimental prototypes to pre-clinical tests; c) the activities of both basic and clinical research necessary to bring our technology to the field of clinical intracranial monitoring.

Most of the probes used in the clinic for recording EEG and ECoG are the macroelectrodes type, with dimensions ranging from a few tens of microns (> 500 microns) to a few millimeters (1-2 mm). The use of such electrodes has played a key role in the development of new functional therapies used successfully in the treatment of various neurological diseases such as Parkinson‘s disease, Epilepsy or chronic intractable pain.

microfluidic microprobes detail for Epilepsy Research

microfluidic microprobes detail for Epilepsy Research

The project proposes the design of cutting-edge biomedical technologies focused on the development of fProbes, integrated probes for neural recording and delivery of drugs in local, currently marketed by microLIQUID in the field of basic neuroscience. It is planned to evaluate the clinical and technical aspects associated with its implementation as a solution to the problem of intracranial clinical monitoring of refractory epilepsy and intracerebral hemorrhage, stroke and traumatic brain injury.

fProbes is the trademark under which microLIQUID is currently marketing our integrated fluidic solutions for neural recording and drug delivery in local in the field of neuroscience

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MICROFLUIDIC EVENT: MICROLIQUID IN FLOWING MATTER 2016

Posted By Borja Barredo / Blog With Right Sidebar, News / 2016, Branding Components, Earth Sciences event, Flowing matter, HTML, january, Laura Campo Deaño, Life, microfluidics, microLIQUID, Newtonian fluid, Nuno Araújo, Platform, Porto, Porto University, Portugal, Video, Web Design, WordPress / No hay comentarios

Microfluidic Event in Portugal

MicroLIQUID has been present and participating in the FLOWING MATTER 2016

Our company moves to Porto to be present at the conference acting as one of the sponsors of the Event.

 

microfluidic Flow sensor

microfluidic Flow sensor

microfluidic conference FLOWING MATTER 2016

microfluidic conference FLOWING MATTER 2016

In the next link we can see all the companies invited as sponsors:

http://www.campodeano.com/FlowingMatter/Sponsors.html

Flowing matter lies at the crossroads between industrial processes, fundamental physics, engineering and Earth Sciences. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions.

A fundamental understanding of flowing matter is still missing impeding scientific progress, effective control on industrial processes, as well as accurate predictions of natural phenomena. Flowing matter frequently presents a tight coupling between small-scale structures and large-scale flow urging for a unifying approach. The Action will coordinate existing research efforts into a synergetic plan of collaborations and exchanges to develop an innovative multi-scale approach able to encompass the traditional micro-, meso-, and macro-scales descriptions.

Breakthroughs in the understanding of flowing matter will impact on fundamental key scientific issues, such as the glass, the elasto-plastic and the jamming transitions, as well as industrial applications including health, energy, cosmetics, detergents, food, paints, inks, oil and gas. The conference has covered the three main topics of the COST Action: complex fluids, active matter and complex flows.

The Local Organizers of the conference (Laura Campo Deaño and Nuno Araújo are Microliquid partners, Porto University people, and we are proud and happy for this mutual collaboration.

The event has been a total success and sure that in a near future in many other things or in next editions we will collaborate again. Great work from the Porto Team!!!

Microfluidic Event in Porto, full of attendants

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Proyecto Financiado por MINECO: Microfluidic Chip Biosensor based in DNA – INNPACTO Subprogram

Posted By Borja Barredo / News / Biosensor, DNA, microfluidics, microLIQUID / No hay comentarios

Microfluidic Chip: Biosensor based on DNA

microLIQUID has participated in a public funded project by the MINISTERIO de ECONOMÍA Y COMPETITIVIDAD through the INNPACTO Subprogram (Reference Number: IPT-2011-1290-010000)

OBJETIVOS

Desarrollo de un BIOSENSOR Universal basado en ADN para Diagnóstico rápido de patógenos: aplicación específica asociada a producción en ganado bovino

El objetivo principal de este proyecto financiado con fondos públicos es el diseño, desarrollo y validación de un novedoso dispositivo universal abierto, compacto, de fácil manejo basado en la tecnología Microarray LDR con una fase pre-analítica que permita trabajar sobre diferentes matrices y que posibilite una rápida detección e identificación inequívoca simultánea de patógenos responsables de patologías infecciosas asociadas a producción en ganado bovino, incluyendo el estudio de bacterias, algas, mohos y virus.

microfluidic biosensor of DNA

Microfluidic Chip: biosensor of DNA

Como Objetivos específicos:

Validación del prototipo, Pre diseño Industrial del microarray  y diseño del sistema Lab on a Chippara su posible comercialización, fase previa para el establecimiento de un sistema de prestación de servicios clínicos con el microarray.

Se complementa con una aplicación específica para detección precoz en etapa subclínica de patógenos, de difícil erradicación asociados a la producción en bovinos, válido para diferentes matrices (leche, ubre o muestras ambientales)basada en la tecnología de microarray (dispositivo Lab on a Chip)

Implantación y nuevos desarrollos de las últimas tecnologías y sistemáticas de diagnóstico rápidas basadas en métodos moleculares rápidos automatizables con alta densidad de integración de dianas (análisis simultáneo de cientos de resultados) con menos exigencia de recursos, de coste ajustado, amistosas y que no requieren personal tan cualificado, este caso para el diagnostico precoz de MAMITIS, especialmente en ausencia de sintomatología(etapa subclínica), específicamente aplicada a la realidad de las granjas.

Que el tiempo de diagnóstico sea inferior a 24 horas, para tomar acciones mejores y más rápidas en el control preventivo de esta enfermedad, especialmente en casos asintomáticos como en la mamitis subclínica.

Desarrollar una herramienta válida para el control preventivo de mamitis y por tanto para control de riesgo en granja.

Microfluidics laboratory

La propuesta tecnológica diseñada se basa en un biochip de ADN de cámara múltiple asociado a una plataforma de microarray y a una PCR integradas donde:
– El biosensor integra todas las etapas del proceso (extracción, amplificación y detección) en un único dispositivo con una seguridad diagnóstica muy superior a los métodos tradicionales, permitiendo incluso portabilidad.
– Se utiliza la novedosa tecnología de la reacción de detección de la ligasa (LDR), más eficiente, especifica y rápida con un microarray universal que permite un diseño configurable según el grupo/s que interese identificar permitiendo escoger perfiles específicos de biotipos de zonas características y añadir o modificar especies en el mismo chip con el consecuente ahorro en costes.
– La combinación de sondas en la reacción de ligación y de un microarray universal crea un sistema integral, compacto, completamente abierto que en cada momento se puede adaptar a las necesidades del usuario, empleando más o menos sondas o intercambiándolas a conveniencia. No hay soluciones tecnológicas comercializadas equiparables en el mercado.
La primera aplicación diseñada pertenece al sector agroalimentario y salud animal. Su selección de debe al elevado número de diferentes especies y grupos diana involucrados que comparte con numerosas patologías (incluyendo salud humana) Grupos de especies incluidos en el biosensor), experiencia del grupo investigador, así como orientación al mercado dada su relación directa con la productividad entre otros aspectos

PARTICIPANTES

REIA Análisis Especiales S.A. , Universidades de Santiago de Compostela ,  microLIQUID S.L. Feiraco S. Coop Gallega, Vacunek S.L. e IK4-Ikerlan 

DURACIÓN

2011- 2013

FINANCIACIÓN

MINECO – Subprograma INNPACTO  (Nº Exp: IPT-2011-1290-010000)

MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

 

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