Microfluidic Probes for EPILEPSY Research
Microfluidic microprobes to record neuronal activity and local application of drugs, to be applied to the electrophysiological monitoring or pre-surgical intra-operative of adult patients with refractory epilepsy, awarded with the FIPSE Project in Phase 1.
This project, coordinated by the Department of Neurophysiology at the Hospital Marqués de Valdecilla-Valdecilla Health Research Institute (IDIVAL) (Dr. José Luis Fernández Torre), integrates researchers from the CSIC Cajal Institute in Madrid (Dr. Liset Menendez de la Prida ) and the microLIQUID in Basque Country (Dr. Ane Altuna), a multidisciplinary team with a long research career in their respective fields of expertise.
Dr. José Luis Fernández Torre is the principal investigator of this project, is Head of Clinical Neurophysiology, University Hospital Marqués de Valdecilla, Vice president of the National Committee for Clinical Neurophysiology, Associate Professor in the Department of Physiology and Pharmacology, Faculty of Medicine Santander (UNICAN) and creator and in charge of the Research group for clinical research associate of Neurophysiology in Epilepsy and Neurointensives in the Valdecilla Research Institute (IDIVAL). He has published over 80 articles in prestigious journals such as Clinical Neurophysiology, Epilepsy, Neurology and Journal Neurology, Neurosurgery and Psyschiatry.
Liset Menendez de la Prida is doctor in Neuroscience (1998) in the program of the prestigious Institute of Neurosciences of Alicante, is an international expert in the study of the neural mechanisms of high frequency oscillations (or HFOs) in epilepsy. She has participated in numerous international projects of the European Commission and prestigious institutions such as the Human Frontier Science Program, and published in the top journals in the field as Neuron and Nature Neuroscience. It has 5 accredited six-year research periods for her scientific activity, she has directed four doctoral theses and has 2 ongoing, and regularly participates as a speaker at the prestigious Gordon Conference on Epilepsy and guest in prestigious foreign institutions.
Ane Altuna is doctor by the University of the Basque Country (2012), currently head of R & D in Microliquid, she developed her career in science and technology in IKERLAN where she designed and finalized the production of integrated electrical probes for brain recording. Expert in SU-8, biocompatible polymer that makes up the structural material of our integrated probes, has published her work in the most prestigious journals in the field, such as Lab-on-chip or Biosensors and Bioelectronics.
The aim of the project is to assess the feasibility of integrated microscopic probes (<150 microns diameter) aimed to record neuronal activity and to deliver drugs locally for preoperative or intraoperative electrophysiological monitoring of adult patients with refractory epilepsy evaluated for surgery or and neurocritical patients (in coma) with spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, malignant stroke and severe head trauma during continuous multimodal monitoring. With this project they intend to evaluate: a) the clinical opportunity for intracranial integrated recordings and local drug delivery solutions; b) the technical adjustments required to bring current experimental prototypes to pre-clinical tests; c) the activities of both basic and clinical research necessary to bring our technology to the field of clinical intracranial monitoring.
Most of the probes used in the clinic for recording EEG and ECoG are the macroelectrodes type, with dimensions ranging from a few tens of microns (> 500 microns) to a few millimeters (1-2 mm). The use of such electrodes has played a key role in the development of new functional therapies used successfully in the treatment of various neurological diseases such as Parkinson‘s disease, Epilepsy or chronic intractable pain.
The project proposes the design of cutting-edge biomedical technologies focused on the development of fProbes, integrated probes for neural recording and delivery of drugs in local, currently marketed by microLIQUID in the field of basic neuroscience. It is planned to evaluate the clinical and technical aspects associated with its implementation as a solution to the problem of intracranial clinical monitoring of refractory epilepsy and intracerebral hemorrhage, stroke and traumatic brain injury.
fProbes is the trademark under which microLIQUID is currently marketing our integrated fluidic solutions for neural recording and drug delivery in local in the field of neuroscience