World Osteoporosis Day: Developing a new Microfluidic POC System for early-stage osteoporosis detection

Posted By J. Garcia / Sin categoría / biotechnology, bone disease, diagnostic test, ivd, microfluidic technologies, microLIQUID, osteoporosis, PoCOsteo, point-of-care tool, porous bone / No hay comentarios


World Osteoporosis Day takes place every year on October 20.


Because of the ageing of the society, osteoporosis (literally “porous bone”) and its complications is becoming more and more prevalent, making the bone disease a health priority in many parts of the world.


Currently, osteoporosis is commonly known as a “silent killer” disease. Usually osteoporosis manifests itself in a drastic manner, i.e. through fracture of the osteoporotic bone in the affected individual. Until now little or no measures for prevention or early detection of this disease are taken, because no simple, yet sufficiently precise or sensitive tools for early detection of individuals at risk of osteoporosis are available, there is a need to develop a efficient rapid diagnostics test to detect the disease.


At microLIQUID we are proud to be able to help with our expertise in microfluidic IVD system development in this cause by being part of PoCOsteo. We are working hand in hand together with European leaders, both from academia and industry, to develop new  POC applications by using the latest microfluidic technologies applied to diagnostics.


The overall objective of the currently proposed PoCOsteo project is a IVD Point-of-care development. Also, the clinical validation and preparation for commercialization of thePoint-of-Care tool for bone disease. The osteoporosis prevention, osteoporosis detection and osteoporosis treatment is our aim.


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Precise Replica Moulding

Posted By J. Garcia / microfluidics, Technology Blog / biotechnology, microfluidics, microLIQUID, mould / No hay comentarios



microfluidic-moldingThe use of durable replica moulds with high-feature resolution has been proposed as an inexpensive and convenient route for the manufacture of microstructured materials. A simple and fast duplication method, it involves the use of a master mould to create durable polymer replicas, using polydimethylsiloxane (PDMS). The application of PDMS offers numerous advantages due to its intrinsic properties such as its biocompatibility, affordable price, transparency (240nm-1100nm) as well as its low autofluorescence. The replica process enables fast and easy manufacturing since it can be covalently stuck to a glass substrate, using plasma treatment to form sealed microfluidic devices. The replica process is clean and precise, while multiple replications can be obtained from one master. This dramatically decreases both the expenditure and the time required to create specific patterns that need to be used consistently in the creation of various devices.



High Precision SU-8 Master Mould for Microfluidic Device Replication

microLIQUID manufactures polymer SU-8 master moulds on silicon wafers, which are widely used to produce microfluidic disposables in the development and prototyping stage. In addition, we generate series of PDMS copies with excellent reproducibility and precision. microLIQUID offers high resolution moulds with a standard deviation of under 2%. microLIQUID is working in applications such as droplet generation for PCR diagnostics, single-cell analysis and high throughput screening among others. The moulds are highly reusable since we offer several treatments to increase the service life of the mould. This replica method will help you choose the optimum design for your product prior to scaling up to mass production. Indeed, more than 50 companies all over the world have already done so.

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Celebrating our 10th anniversary!

Posted By J. Garcia / News / 10th anniversary, biotechnology, microfluidics, microLIQUID / No hay comentarios



microLIQUID would like to take this opportunity to announce that it has achieved another major milestone by completing 10 years in business


The company is now celebrating a decade working on the design and manufacture of novel microfluidic products for our customers; we are proud and delighted to have made it this far, and excited about the future!


During this time, we´ve grown in many ways, for example by increasing the number of employees and clients, as well as boosting revenues. We have collaborated successfully in more than 300 microfluidic projects around the world, doubling our turnover since 2014 and we have gained vast experience in this business dimension. In addition, we develop new value propositions to our customers, offering unique complete value chain solutions from complex microfluidic consumables that can be processed on our own design automated instrumentation (e.g. Point of Care instruments).


Since its establishment, microLIQUID has focused on delivering quality to its customers and fulfilling their expectations. This is the reason why so many of our clients and partners trust our professionalism and appreciate the individual approach we provide.


We are grateful to all those who have worked with us and have helped us over these last 10 years to develop our company. microLIQUID´s success would not have come to fruition had it not been for their unwavering support.


We are optimistic about what lies ahead and are very confident that we will be able to help many more future customers around the world to manufacture solutions based on our microfluidics and automated instrument solutions in fields such as rapid testing, immuno-oncology, NGS and Precision medicine, liquid biopsy and drug delivery among others.


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Microfluidics Manufacturing: Clean Room Facilities

Posted By Borja Barredo / Technology Blog / microfluidic, microfluidics, microLIQUID / No hay comentarios

Clean room distribution in microLIQUID

Clean room distribution in microLIQUID for microfluidics

Microfluidics Manufacturing: Clean Room Facilities

microLIQUID has  in-house the means to work in microfluidics and medical devices. Our main facilities are:

INJECTION MOLDING CLEAN ROOM  – ISO 7&8 for silicone and thermoplastic components.

EXTRUSION CLEAN ROOM  – ISO 7&8 for silicone tubing and silicone and thermoplastic catheters.

LABORATORY AND TESTING CLEAN ROOM –  for project development & testing activities.




Clean Room Facility

Clean Room Facility


These means allow the company to develop:

Integration of the microfluidic manufacturing with biotechnological process treatments in the same manufacturing line ( surface treatmentes, Ag/Ab immobilization, freeze-drying etc) , Point of Care and Point of use Microfluidic Cartridges

Also, the company has the means to characterise and validate the microfluidic functionality required for final applications, with a Lab dedicated

microLIQUID has developed products for Biotech companies where the microfluidic development is done at the same time that the packaging and the equipment respecting the automation and the miniaturization (E.g.  qPCR, test ELISA  etc)


Clean Room Facilities for microfluidics

Clean Room Facilities for microfluidics

In our 400 m2 Clean Room Facility , the company does:


Chemical Processes

Design and simulation



Biological pre-validation

Some Activities & Processes:




Sputtering Metals

Hot Embossing etc…..


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microLIQUID joins Food for Life-Spain Technological Platform

Posted By Borja Barredo / News / Lab on a Chip, microfluidics, microLIQUID / No hay comentarios

MicroLIQUID has reached an agreement to join the technology platform FOOD FOR LIFE – Spain(PTF4LS), working on the development of detection systems in Food & Health, along with Food Security.

Food for Life- Spain logo

Food for Life- Spain

Technology Platforms like this, are a group of stakeholders in a particular sector, led by industry, with the aim of defining a Strategic Research Agenda (acronym: SRA) on important issues and great social relevance, in which achieve European objectives of growth, competitiveness and sustainability depend on technological advances and research in the medium and long term.

Technology Platforms are based on the definition of a Strategic Research Agenda and mobilizing the critical mass of research and innovation effort needed.
Guide research in supply to industrial interests and the interests of society. The aim of this platform is to reach a consensus among all (companies and researchers) on issues of interest to be investigated. This consensus will materialize in the development of a Strategic Research Agenda.

The intention is that projects to be submitted to the various national R & D + Innovation plans are made based on the needs of the sector and not just those of the research centers or other stakeholders only.

microLIQUID joins in the project based on the capacity of the company of generating new detection systems in the Food & Health sector, like the example we see in the picture

point of care and detection systems based in microfluidics

microLIQUID develops and manufactures  new detection systems based in microfluidics in the Food & Health sector





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Distribution Agreement fProbes microLIQUID – Cibertec in Spain

Posted By Borja Barredo / News / cibertec, Earth Sciences event, epilepsy, Ikerlan, microfluidics, microLIQUID, Neurology, neuron, Neuronal, Neurophysiology, Neuroscience / No hay comentarios

microLIQUID signs a distribution agreement with Cibertec , Key distributor of neuronal microprobes fProbes in Spain.



microfulidic microprobes fProbes

microfluidic microprobes fProbes


On February 26 was made official the agreement that the two companies have signed for the distribution of the neuronal microprobes Fprobes for research in EPILEPSY, PARKINSON and other BRAIN DISEASES. Cibertec will be the exclusive dealer entitled to sell the product in the Spanish national market.

Cibertec is the Spanish leader in production and distributor of devices and equipment for research and teaching in neurology and in several other fields. The company was constituted in 1977 and was born as a manufacturer of a limited number of equipment, range of stimulators and electrophysiology window discriminator, but with an advanced design.

Over the years Cibertec have been manufacturing a wide range of new equipment, mostly under specifications of its customers, and at the same time marketing products manufactured by prestigious companies.

The new distribution agreement allows Cibertec to sell the fProbes and the fPack, and also the developments coming soon in the Neuro field by microLIQUID.

The fProbes are probes with integrated electrophysiological recording and the simultaneous release of drugs in the brain with ,currently, experimental purposes. For proper functionality, fProbes are integrated in a package, the fPack, which ensures the electrical and fluidic connection.
This technology has been developed as a result of scientific collaboration between the Cajal Institute CSIC, the IKERLAN Technology Centre and the
University of Zaragoza

Here you can find the link where all is explain in deep:

Both companies have started to work the Beta Tester Program for a better landing in the market. This beta program is simply the starting point, offering to researchers a pack of one encapsulate and 5 units of the probes, in order to test the product.

Microliquid has found a perfect strategic partner to output its own product and at the same time Cibertec complete its product portfolio with a unique product in the market.
The advantages of this agreement are clear and the complementary fields of both companies allow developing the market together.

CIBERTEC Neuroscience

CIBERTEC Neuroscience –

microLIQUID expert in microfluidics

microLIQUID expert in microfluidics –

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Posted By Borja Barredo / Blog With Right Sidebar, News / 2016, Branding Components, Earth Sciences event, Flowing matter, HTML, january, Laura Campo Deaño, Life, microfluidics, microLIQUID, Newtonian fluid, Nuno Araújo, Platform, Porto, Porto University, Portugal, Video, Web Design, WordPress / No hay comentarios

Microfluidic Event in Portugal

MicroLIQUID has been present and participating in the FLOWING MATTER 2016

Our company moves to Porto to be present at the conference acting as one of the sponsors of the Event.


microfluidic Flow sensor

microfluidic Flow sensor

microfluidic conference FLOWING MATTER 2016

microfluidic conference FLOWING MATTER 2016

In the next link we can see all the companies invited as sponsors:

Flowing matter lies at the crossroads between industrial processes, fundamental physics, engineering and Earth Sciences. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions.

A fundamental understanding of flowing matter is still missing impeding scientific progress, effective control on industrial processes, as well as accurate predictions of natural phenomena. Flowing matter frequently presents a tight coupling between small-scale structures and large-scale flow urging for a unifying approach. The Action will coordinate existing research efforts into a synergetic plan of collaborations and exchanges to develop an innovative multi-scale approach able to encompass the traditional micro-, meso-, and macro-scales descriptions.

Breakthroughs in the understanding of flowing matter will impact on fundamental key scientific issues, such as the glass, the elasto-plastic and the jamming transitions, as well as industrial applications including health, energy, cosmetics, detergents, food, paints, inks, oil and gas. The conference has covered the three main topics of the COST Action: complex fluids, active matter and complex flows.

The Local Organizers of the conference (Laura Campo Deaño and Nuno Araújo are Microliquid partners, Porto University people, and we are proud and happy for this mutual collaboration.

The event has been a total success and sure that in a near future in many other things or in next editions we will collaborate again. Great work from the Porto Team!!!

Microfluidic Event in Porto, full of attendants

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Proyecto Financiado por MINECO: Microfluidic Chip Biosensor based in DNA – INNPACTO Subprogram

Posted By Borja Barredo / News / Biosensor, DNA, microfluidics, microLIQUID / No hay comentarios

Microfluidic Chip: Biosensor based on DNA

microLIQUID has participated in a public funded project by the MINISTERIO de ECONOMÍA Y COMPETITIVIDAD through the INNPACTO Subprogram (Reference Number: IPT-2011-1290-010000)


Desarrollo de un BIOSENSOR Universal basado en ADN para Diagnóstico rápido de patógenos: aplicación específica asociada a producción en ganado bovino

El objetivo principal de este proyecto financiado con fondos públicos es el diseño, desarrollo y validación de un novedoso dispositivo universal abierto, compacto, de fácil manejo basado en la tecnología Microarray LDR con una fase pre-analítica que permita trabajar sobre diferentes matrices y que posibilite una rápida detección e identificación inequívoca simultánea de patógenos responsables de patologías infecciosas asociadas a producción en ganado bovino, incluyendo el estudio de bacterias, algas, mohos y virus.

microfluidic biosensor of DNA

Microfluidic Chip: biosensor of DNA

Como Objetivos específicos:

Validación del prototipo, Pre diseño Industrial del microarray  y diseño del sistema Lab on a Chip, para su posible comercialización, fase previa para el establecimiento de un sistema de prestación de servicios clínicos con el microarray.

Se complementa con una aplicación específica para detección precoz en etapa subclínica de patógenos, de difícil erradicación asociados a la producción en bovinos, válido para diferentes matrices (leche, ubre o muestras ambientales)basada en la tecnología de microarray (dispositivo Lab on a Chip)

Implantación y nuevos desarrollos de las últimas tecnologías y sistemáticas de diagnóstico rápidas basadas en métodos moleculares rápidos automatizables con alta densidad de integración de dianas (análisis simultáneo de cientos de resultados) con menos exigencia de recursos, de coste ajustado, amistosas y que no requieren personal tan cualificado, este caso para el diagnostico precoz de MAMITIS, especialmente en ausencia de sintomatología(etapa subclínica), específicamente aplicada a la realidad de las granjas.

Que el tiempo de diagnóstico sea inferior a 24 horas, para tomar acciones mejores y más rápidas en el control preventivo de esta enfermedad, especialmente en casos asintomáticos como en la mamitis subclínica.

Desarrollar una herramienta válida para el control preventivo de mamitis y por tanto para control de riesgo en granja.

Microfluidics laboratory

La propuesta tecnológica diseñada se basa en un biochip de ADN de cámara múltiple asociado a una plataforma de microarray y a una PCR integradas donde:
– El biosensor integra todas las etapas del proceso (extracción, amplificación y detección) en un único dispositivo con una seguridad diagnóstica muy superior a los métodos tradicionales, permitiendo incluso portabilidad.
– Se utiliza la novedosa tecnología de la reacción de detección de la ligasa (LDR), más eficiente, especifica y rápida con un microarray universal que permite un diseño configurable según el grupo/s que interese identificar permitiendo escoger perfiles específicos de biotipos de zonas características y añadir o modificar especies en el mismo chip con el consecuente ahorro en costes.
– La combinación de sondas en la reacción de ligación y de un microarray universal crea un sistema integral, compacto, completamente abierto que en cada momento se puede adaptar a las necesidades del usuario, empleando más o menos sondas o intercambiándolas a conveniencia. No hay soluciones tecnológicas comercializadas equiparables en el mercado.
La primera aplicación diseñada pertenece al sector agroalimentario y salud animal. Su selección de debe al elevado número de diferentes especies y grupos diana involucrados que comparte con numerosas patologías (incluyendo salud humana) Grupos de especies incluidos en el biosensor), experiencia del grupo investigador, así como orientación al mercado dada su relación directa con la productividad entre otros aspectos


REIA Análisis Especiales S.A. , Universidades de Santiago de Compostela ,  microLIQUID S.L. Feiraco S. Coop Gallega, Vacunek S.L. e IK4-Ikerlan 


2011- 2013


MINECO – Subprograma INNPACTO  (Nº Exp: IPT-2011-1290-010000)




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