Microfluidic Application in the Neuro field
An innovative project with Hospital de Valdecilla(IDIVAL), together with microLIQUID and CSIC reaches the centre of the technology talent, the MIT in Boston.
A project lead by the Head of Clinical Neurophysiology and the attending physician of Intensive Care Medicine of HUMV and IDIVAL, has been one of the 15 international teams selected by MIT #Idea2Global program, developed by the prestigious Massachusetts Institute of Technology (MIT) in Boston (USA). The project has been developed in close collaboration with Instituto Cajal and Microliquid.
The selected teams have won 6 months of training and mentoring of their innovation projects with professors at MIT and other world-class institutions. The program will provide intensive training in innovation methods, development of collaborative projects and specific mentoring team. Moreover, it will provide the experience to help the projects to change from being a new idea to work in the real life.
WHICH IS THE PROJECT?
The idea of the project of great level of technology comes out from Valdecilla, and through the “Foundation for Innovation and Foresight in Health in Spain” (Fipse), which is a non-profit private entity on health research with the Ministry of health and pharmaceutical companies coverage, has gone to the Technology institute in Massachusetts (MIT) in Boston.
The aim of it is to prevent the supervening brain damage while a patient is in coma. And the way to achieve it is the creation of an innovative electrode capable of detecting phenomena which cause the death of neurons that exacerbate the initial injury.
More information at EL DIARIO MONTAÑES
On February 26 was made official the agreement that the two companies have signed for the distribution of the neuronal microprobes Fprobes for research in EPILEPSY, PARKINSON and other BRAIN DISEASES. Cibertec will be the exclusive dealer entitled to sell the product in the Spanish national market.
Cibertec is the Spanish leader in production and distributor of devices and equipment for research and teaching in neurology and in several other fields. The company was constituted in 1977 and was born as a manufacturer of a limited number of equipment, range of stimulators and electrophysiology window discriminator, but with an advanced design.
Over the years Cibertec have been manufacturing a wide range of new equipment, mostly under specifications of its customers, and at the same time marketing products manufactured by prestigious companies.
The new distribution agreement allows Cibertec to sell the fProbes and the fPack, and also the developments coming soon in the Neuro field by microLIQUID.
The fProbes are probes with integrated electrophysiological recording and the simultaneous release of drugs in the brain with ,currently, experimental purposes. For proper functionality, fProbes are integrated in a package, the fPack, which ensures the electrical and fluidic connection.
This technology has been developed as a result of scientific collaboration between the Cajal Institute CSIC, the IKERLAN Technology Centre and the
University of Zaragoza
Here you can find the link where all is explain in deep:
Both companies have started to work the Beta Tester Program for a better landing in the market. This beta program is simply the starting point, offering to researchers a pack of one encapsulate and 5 units of the probes, in order to test the product.
Microliquid has found a perfect strategic partner to output its own product and at the same time Cibertec complete its product portfolio with a unique product in the market.
The advantages of this agreement are clear and the complementary fields of both companies allow developing the market together.
Microfluidic Probes for EPILEPSY Research
Microfluidic microprobes to record neuronal activity and local application of drugs, to be applied to the electrophysiological monitoring or pre-surgical intra-operative of adult patients with refractory epilepsy, awarded with the FIPSE Project in Phase 1.
This project, coordinated by the Department of Neurophysiology at the Hospital Marqués de Valdecilla-Valdecilla Health Research Institute (IDIVAL) (Dr. José Luis Fernández Torre), integrates researchers from the CSIC Cajal Institute in Madrid (Dr. Liset Menendez de la Prida ) and the microLIQUID in Basque Country (Dr. Ane Altuna), a multidisciplinary team with a long research career in their respective fields of expertise.
Dr. José Luis Fernández Torre is the principal investigator of this project, is Head of Clinical Neurophysiology, University Hospital Marqués de Valdecilla, Vice president of the National Committee for Clinical Neurophysiology, Associate Professor in the Department of Physiology and Pharmacology, Faculty of Medicine Santander (UNICAN) and creator and in charge of the Research group for clinical research associate of Neurophysiology in Epilepsy and Neurointensives in the Valdecilla Research Institute (IDIVAL). He has published over 80 articles in prestigious journals such as Clinical Neurophysiology, Epilepsy, Neurology and Journal Neurology, Neurosurgery and Psyschiatry.
Liset Menendez de la Prida is doctor in Neuroscience (1998) in the program of the prestigious Institute of Neurosciences of Alicante, is an international expert in the study of the neural mechanisms of high frequency oscillations (or HFOs) in epilepsy. She has participated in numerous international projects of the European Commission and prestigious institutions such as the Human Frontier Science Program, and published in the top journals in the field as Neuron and Nature Neuroscience. It has 5 accredited six-year research periods for her scientific activity, she has directed four doctoral theses and has 2 ongoing, and regularly participates as a speaker at the prestigious Gordon Conference on Epilepsy and guest in prestigious foreign institutions.
Ane Altuna is doctor by the University of the Basque Country (2012), currently head of R & D in Microliquid, she developed her career in science and technology in IKERLAN where she designed and finalized the production of integrated electrical probes for brain recording. Expert in SU-8, biocompatible polymer that makes up the structural material of our integrated probes, has published her work in the most prestigious journals in the field, such as Lab-on-chip or Biosensors and Bioelectronics.
The aim of the project is to assess the feasibility of integrated microscopic probes (<150 microns diameter) aimed to record neuronal activity and to deliver drugs locally for preoperative or intraoperative electrophysiological monitoring of adult patients with refractory epilepsy evaluated for surgery or and neurocritical patients (in coma) with spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, malignant stroke and severe head trauma during continuous multimodal monitoring. With this project they intend to evaluate: a) the clinical opportunity for intracranial integrated recordings and local drug delivery solutions; b) the technical adjustments required to bring current experimental prototypes to pre-clinical tests; c) the activities of both basic and clinical research necessary to bring our technology to the field of clinical intracranial monitoring.
Most of the probes used in the clinic for recording EEG and ECoG are the macroelectrodes type, with dimensions ranging from a few tens of microns (> 500 microns) to a few millimeters (1-2 mm). The use of such electrodes has played a key role in the development of new functional therapies used successfully in the treatment of various neurological diseases such as Parkinson‘s disease, Epilepsy or chronic intractable pain.
The project proposes the design of cutting-edge biomedical technologies focused on the development of fProbes, integrated probes for neural recording and delivery of drugs in local, currently marketed by microLIQUID in the field of basic neuroscience. It is planned to evaluate the clinical and technical aspects associated with its implementation as a solution to the problem of intracranial clinical monitoring of refractory epilepsy and intracerebral hemorrhage, stroke and traumatic brain injury.
fProbes is the trademark under which microLIQUID is currently marketing our integrated fluidic solutions for neural recording and drug delivery in local in the field of neuroscience